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目的探讨小儿神经母细胞瘤伴骨转移的生物学行为特点。方法对１０例误诊、误治的小儿神经母细胞瘤伴骨转移的临床病理资料进行认真复习，并观察其组织学特点。结果神经母细胞瘤的骨转移多见于三岁以上的幼儿；转移部位多见于颅顶骨和胫骨；组织学类型为分化较差的神经母细胞瘤。结论神经母细胞瘤的骨转移是本病的晚期表现，预后极差。
Objective To investigate the biological behavior of neuroblastoma with bone metastasis in children. Methods 10 cases of misdiagnosis and misdiagnosis of children with neuroblastoma with bone metastasis clinical and pathological data were carefully reviewed and observed histological features. Results Bone metastasis of neuroblastoma was more common in children over three years old. The metastatic sites were found in parietal and tibial. The histological type was poorly differentiated neuroblastoma. Conclusion Bone metastasis of neuroblastoma is a late manifestation of this disease, with a very poor prognosis.