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目的:探讨年龄、血基础卵泡刺激素(bFSH)水平对不孕妇女行供精人工授精(AID)结局的影响。方法:回顾性分析郑州大学第一附属医院生殖中心2008年1月~2013年12月成功接受供精人工授精治疗的不孕妇女的年龄、bFSH水平与临床妊娠率、流产率的关系。结果:13 247个AID周期中,<35岁组和≥35岁组诱导排卵的妊娠率分别为28.76%,16.04%;自然周期的妊娠率分别为28.88%,16.93%,不同年龄诱导排卵妊娠率及自然周期妊娠率比较,差异有统计学意义(P<0.05)。2<35岁患者中,bFSH≤10 IU/L组诱导排卵和自然周期的妊娠率均高于bFSH>10 IU/L组(P<0.05),流产率对比均无统计学差异(P>0.05)。3≥35岁患者中,bFSH≤10 IU/L组与bFSH>10 IU/L组诱导排卵或自然周期的妊娠率、流产率均无统计学差异(P>0.05)。结论:年龄是影响AID助孕结局的重要因素之一;基础FSH水平对年龄<35岁患者妊娠结局有一定预测作用;诱导排卵并未明显增加AID妊娠率;AID助孕技术并未增加流产风险。
Objective: To investigate the effects of age and blood basal follicle stimulating hormone (bFSH) on infertile women with artificial insemination (AID). Methods: Retrospective analysis of the relationship between the age, bFSH level and clinical pregnancy rate and abortion rate of infertile women who underwent artificial insemination by the Reproductive Center of the First Affiliated Hospital of Zhengzhou University from January 2008 to December 2013 was retrospectively analyzed. Results: In 13 247 AID cycles, the pregnancy rates of ovulation in 28-year-old group and 35-year-old group were 28.76% and 16.04%, respectively. The pregnancy rates of natural cycle were 28.88% and 16.93% And the natural cycle pregnancy rate, the difference was statistically significant (P <0.05). The pregnancy rates of ovulation and spontaneous cycles in bFSH≤10 IU / L group were significantly higher than those in bFSH> 10 IU / L group (P <0.05) at 2 <35 years of age (P <0.05) ). There was no significant difference in pregnancy rate or miscarriage rate between ovariectomized group and spontaneous cycle in bFSH≤10 IU / L group and bFSH> 10 IU / L group (P> 0.05). CONCLUSIONS: Age is one of the important factors that influence the outcome of AID pregnancy. The basal FSH level predicts the pregnancy outcome in patients <35 years of age. Induction of ovulation does not significantly increase the pregnancy rate of AID. AID does not increase the risk of miscarriage .