目的综述近年来banoxantrone(AQ4N)作为肿瘤治疗增敏药物在国外的研究进展,为国内开发和应用AQ4N提供参考。方法分析、归纳、总结近年来发表的相关文献。结果与结论AQ4N本身对细胞没有毒性,在乏氧条件下经还原酶的催化生成活性药物AQ4,后者通过抑制乏氧细胞中的拓扑异构酶Ⅱ活性而杀死肿瘤乏氧细胞。AQ4N选择性作用于乏氧细胞,与富氧细胞毒性剂如放疗或化疗联合应用,疗效显著。 Objective To summarize the research progress of banoxantrone (AQ4N) as a tumor-sensitizing agent in foreign countries in recent years, and to provide a reference for domestic development and application of AQ4N. Methods to analyze, summarize, summarize the relevant literature published in recent years. RESULTS AND CONCLUSION AQ4N itself is nontoxic to cells and catalyzed by reductase under hypoxic conditions to produce active drug AQ4 which kills tumor hypoxia by inhibiting topoisomerase Ⅱ activity in hypoxic cells. AQ4N selective effect on hypoxic cells, and oxygen-rich cytotoxic agents such as radiotherapy or chemotherapy combined with significant effect.