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目的观察胰岛素强化治疗对2型糖尿病左室舒张功能和高敏C反应蛋白的影响。方法选择初诊2型糖尿病患者90例,随机分为实验组和对照组,行胰岛素强化和口服药治疗,测定左室舒张早期充盈峰值流速、晚期充盈峰值流速、等容舒张时间、空腹及餐后2 h血糖、血脂、高敏C反应蛋白。结果实验组左室舒张功能的指标均显著降低,高敏C反应蛋白较治疗前明显下降。结论胰岛素强化治疗能明显改善左室舒张功能和减轻心肌炎症反应。
Objective To observe the effects of intensive insulin therapy on left ventricular diastolic function and high-sensitivity C-reactive protein in type 2 diabetic patients. Methods Ninety newly diagnosed type 2 diabetic patients were selected and randomly divided into experimental group and control group. Insulin and oral medication were used to measure the peak filling velocity, early peak filling velocity, isovolumic relaxation time, fasting and postprandial 2 h blood glucose, blood lipids, high-sensitivity C-reactive protein. Results The indexes of left ventricular diastolic function in experimental group were significantly decreased, and the content of high sensitive C-reactive protein decreased significantly compared with that before treatment. Conclusion Intensive insulin therapy can significantly improve left ventricular diastolic function and reduce myocardial inflammatory response.