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近年来应用鲎溶解物试验(Limuluslysate Test简称LLT)检测体液内的微量内毒素有助于疾病的诊断及/或预后的判断内毒素是革兰阴性细菌细胞壁上的类脂多糖体。正常人由肠道吸收入门静脉的内毒素,可被肝脏网状内皮系统迅速清除而消失。肝硬化腹水患者常出现内毒素血症(endotoxemia ETM)从而加重肝脏的损害。1984年1～11月,我们对肝炎后肝硬化门脉高压腹水患者以LLT检测腹水和血中内毒素,结果分析如下。
In recent years, the application of Limulus lysate test (Limuluslysate Test referred to as LLT) to detect trace amounts of endotoxin in body fluids contribute to the diagnosis and / or prognosis of the disease. Endotoxins are lipopolysaccharides on the cell walls of Gram-negative bacteria. Normal endotoxin, which is absorbed into the portal vein by the intestine, can be rapidly cleared by the reticuloendothelial system of the liver and disappear. Patients with cirrhosis and ascites often have endotoxemia (endotoxemia) which exacerbates liver damage. From January to November 1984, we detected ascites and endotoxin in the blood by LLT in patients with posthepatitic cirrhosis and portal hypertension. The results are as follows.