AIM: To evaluate a new imaging device for colonoscopy that adds two side viewing CMOS lenses, the Third EyePanoramic. cap.METHODS: In this prospective observational feasibility study, 33 patients, 18 male and 15 female, underwent routine screening, surveillance or diagnostic colonoscopy with the new Third EyePanoramic. cap clipped on to the distal tip of a high definition Fuji EC530-LS Slim Colonoscope. All procedures were performed at the New York Presbyterian-Queens Endoscopy unit by two experienced endoscopists(Rubin M and Kim SH). Main outcome measurements included evaluation of the image quality of the Third EyePanoramic. cap, adenoma detection rate, cecal intubation rate, withdrawal time and total procedure time.RESULTS: The Third EyePanoramic. cap enabled enhanced views without affecting the quality of the colonoscope’s image or its handling characteristics through the colon. Ileal intubation was accomplished in most cases, but was more challenging. The side view lenses detected polyps and diverticula hidden behind folds and in flexures not seen on the standard view.The side view lenses were easily cleaned utilizing an EndogatorIrrigation Pump(Medivators, Minneapolis,MN, United States) by angling the scope tip against the mucosa while washing. The cecum was reached in all33 patients. Mean cecal intubation time was 8.19 ± 2.17 min, mean withdrawal time was 10.15 ± 5.56 min and mean total procedure time was 20.31 ± 5.14 min. The overall adenoma detection rate was 44%.CONCLUSION: The Third EyePanoramic. cap enables wide view colonoscopy with enhanced visualization utilizing standard forward view colonoscopes. AIM: To evaluate a new imaging device for colonoscopy that adds two side viewing CMOS lenses, the Third Eye  Panoramic. Cap. METHODS: In this prospective observational feasibility study, 33 patients, 18 male and 15 female, underwent routine screening, surveillance or diagnostic colonoscopy with the new Third Eye  Panoramic. cap clipped on to the distal tip of a high definition Fuji EC530-LS Slim Colonoscope . All procedures were performed at the New York Presbyterian-Queens Endoscopy unit by two experienced endoscopists (Rubin M and Kim SH). Main outcome measurements included evaluation of the image quality of the Third Eye  Panoramic. Cap, adenoma detection rate, cecal intubation rate, withdrawal time and total procedure time .RESULTS: The Third Eye Panoramic. Cap enabled enhanced opinions without affecting the quality of the colonoscope’s image or its handling characteristics through the colon. Ileal intubation was accomplished in most cases, but was more challenging. The side view lenses detected polyps and diverticula hidden behind folds and in flexures not seen on the standard view. the side view lenses were easily cleaned utilizing an Endogator  Irrigation Pump (Medivators, Minneapolis, MN, United States) by angling the scope tip against the mucosa while The cecum was reached in all 33 patients. Mean cecal intubation time was 8.19 ± 2.17 min, mean withdrawal time was 10.15 ± 5.56 min and mean total procedure time was 20.31 ± 5.14 min. The overall adenoma detection rate was 44%. CONCLUSION: The Third Eye  Panoramic. Cap enables wide view colonoscopy with enhanced visualization utilizing standard forward view colonoscopes.