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目的探讨通心络胶囊对高血压伴糖尿病患者血管内皮功能和氧化应激的影响。方法选择2009年1月—2014年1月收治的176例高血压伴糖尿病患者作为研究对象,随机分为对照组87例和观察组89例。对照组给予常规治疗,观察组在对照组的基础上口服通心络胶囊,4粒/次,3次/d,两组均连续治疗两周。记录治疗前后两组患者SBP、DBP、FPG、PBG水平。比较血清超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、内皮素(endothelin,ET)-1、一氧化氮(nitric oxide,NO)水平。计量资料组间比较采用t检验,组内比较采用配对t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗后,观察组与对照组SBP、DBP水平分别为(121.3±8.4)、(137.2±9.3)、(68.3±7.9)、(79.4±8.2)mm Hg(1 mm Hg=0.133 k Pa),均较治疗前的(167.6±11.4)、(169.2±11.3)、(98.7±9.3)、(98.2±9.4)mm Hg明显下降,差异均有统计学意义(均P<0.05)。治疗后两组SBP、DBP水平比较差异均有统计学意义(均P<0.05)。治疗后,观察组与对照组MDA、ET-1水平分别为(4.01±0.43)、(5.31±0.46)?mol/L、(46.2±5.1)、(56.2±5.3)ng/L,较治疗前的(6.23±0.51)、(6.21±0.52)?mol/L、(66.5±8.1)、(67.4±8.2)ng/L明显下降,差异均有统计学意义(均P<0.05)。治疗后,观察组SOD、NO水平分别为(125.7±7.9)U/ml、(78.4±8.9)?mol/L,均较治疗前的(53.6±6.3)U/ml、(52.5±7.1)?mol/L明显上升,差异均有统计学意义(均P<0.05)。治疗后,观察组MDA、ET-1、SOD、NO水平,与对照组[(5.31±0.46)?mol/L、(56.2±5.3)ng/L、(71.2±6.8)U/ml、(67.5±8.5)?mol/L]比较差异均有统计学意义(均P<0.05)。结论通心络胶囊能有效的逆转氧化应激所致的损伤,降低氧化应激水平,改善血管内皮功能,延缓高血压的进展。
Objective To investigate the effect of Tongxinluo capsule on vascular endothelial function and oxidative stress in hypertensive diabetic patients. Methods A total of 176 hypertensive diabetic patients admitted from January 2009 to January 2014 were randomly divided into control group (n = 87) and observation group (n = 89). The control group was given routine treatment. The observation group was given Tongxinluo capsule 4 times a day for 3 times daily on the basis of the control group, and the two groups were treated continuously for two weeks. The SBP, DBP, FPG and PBG levels of two groups before and after treatment were recorded. Serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), endothelin (ET) -1 and nitric oxide (NO) were compared. Measurement data were compared between groups using t test, the group was compared using paired t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results After treatment, the SBP and DBP levels in the observation group and control group were (121.3 ± 8.4), (137.2 ± 9.3), (68.3 ± 7.9), (79.4 ± 8.2) mm Hg (1 mm Hg = 0.133 kPa) (167.6 ± 11.4), (169.2 ± 11.3), (98.7 ± 9.3) and (98.2 ± 9.4) mm Hg before treatment, respectively. The difference was statistically significant (all P <0.05). The SBP and DBP levels in the two groups after treatment were significantly different (all P <0.05). After treatment, the levels of MDA and ET-1 in the observation group and the control group were (4.01 ± 0.43), (5.31 ± 0.46) mol / L, (46.2 ± 5.1) and (56.2 ± 5.3) ng / L, (6.23 ± 0.51), (6.21 ± 0.52) mol / L, (66.5 ± 8.1) and (67.4 ± 8.2) ng / L, respectively. The difference was statistically significant (all P <0.05). After treatment, the levels of SOD and NO in the observation group were (125.7 ± 7.9) U / ml and (78.4 ± 8.9)? Mol / L respectively, which were significantly higher than those before treatment (53.6 ± 6.3) U / ml and mol / L increased significantly, the differences were statistically significant (P <0.05). After treatment, the levels of MDA, ET-1, SOD and NO in the observation group were significantly higher than those in the control group [(5.31 ± 0.46) mol / L, (56.2 ± 5.3) ng / L, (71.2 ± 6.8) U / ± 8.5) mol / L] (all P <0.05). Conclusion Tongxinluo Capsule can effectively reverse the oxidative stress-induced injury, reduce the level of oxidative stress, improve endothelial function and delay the progression of hypertension.