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目的 探讨部分毒物内服时对人胃粘膜的损伤及其规律性。方法 对１６４ 例内服毒物自杀的患者在洗胃后即时由专人操作内窥镜查，观察胃底、胃体、胃窦部，分别在以上各处钳取粘膜组织２～６ 块，ＨＥ染色镜检，对内镜观察结果分级分度，对８ 例患者进行了１０ｄ ～６ｍｏ 的随访。结果 １６４ 例１００ ％ 异常，对照组中１８ 例异常（１８ ．０％ ），两组比较有显著性差异（ Ｐ＜ ０．０１），胃粘膜病变为具有特征性的急性出血性糜烂性胃炎，随着中毒症状的恶化、内服毒物量的增加及毒性的上升，胃粘膜损伤加重，随着病情的改善而改善。结论 粘膜损伤是毒物内服时全身病变的一部分。
Objective To investigate the damage and regularity of human gastric mucosa when some toxicants are administered orally. Methods One hundred and sixty-four patients who took suicide with oral drug poisoning were treated with endoscopy immediately after gastric lavage. The gastric fundus, gastric body and gastric antrum were observed. The mucosal tissues were dissected from 2 to 6 above, Inspection, endoscopic observation results grading, 8 patients were followed for 10d ~ 6mo. Results There were 164 cases of 100% abnormalities and 18 cases of abnormalities (18.0%) in the control group. There were significant differences between the two groups (P <0.01). The gastric mucosal lesions were characterized by acute hemorrhagic erosive gastritis, With the deterioration of the symptoms of poisoning, the increase in the amount of oral poisons and the increase of toxicity, gastric mucosal injury increases, with the improvement of the disease and improve. Conclusions Mucosal injury is part of systemic pathology when poisons are administered orally.