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目的：观察比较单剂枢复宁联合方案与胃复安联合方案预防大剂量顺铂化疗所致恶心呕吐的疗效。方法：将４９例接受大剂量顺铂化疗的患者随机分为枢联组和胃联组，比较两组急性和迟发性恶心呕吐的控制率。结果：枢联组和胃联组预防急性呕吐的有效率分别为８８％和６０％（Ｐ＜０．０５）；两组预防急性恶心和迟发性恶心、呕吐的有效率均无显著性差异。结论：单剂枢复宁联合方案对急性呕吐的控制效果优于胃联方案，效价比高，值得推广。
OBJECTIVE: To compare the efficacy of single-agent Shufu Ning combined regimen and Weifuan regimen in the prevention of nausea and vomiting caused by high-dose cisplatin chemotherapy. METHODS: Forty-nine patients receiving high-dose cisplatin chemotherapy were randomly divided into a pivotal group and a stomach-associated group. The control rates of acute and delayed nausea and vomiting were compared between the two groups. Results: The effective rates of prevention of acute vomiting were 88% and 60% in the pivotal group and the Weilian group, respectively (P<0.05). There was no significant difference in the effectiveness of preventing nausea and vomiting between acute nausea and delayed nausea. . Conclusion: The single-agent Shufu Ning combined regimen has better control effect on acute vomiting than the stomach-associated regimen, and has a high potency ratio and is worthy of promotion.