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目的研究异前列腺素(8isoPGF2a)在慢性阻塞性肺疾病(COPD)发病中的作用及其意义。方法选取2005年9月至2006年9月河南省胸科医院呼吸内科住院COPD患者61例,其中急性发作期(AECOPD)38例,稳定期23例;另选18名健康体检者为正常对照组,分别测定血清8isoPGF2a和肺功能。结果AECOPD组血清8isoPGF2a质量浓度为(6.84±1.70)μg/L,明显高于稳定期COPD组的(5.82±1.72)μg/L和健康对照组的(4.64±1.24)μg/L,差异有显著性意义(P<0.05和P<0.01)。AECOPD吸烟组血清8isoPGF2a质量浓度为(7.21±1.67)μg/L,比非吸烟组(5.78±1.44)μg/L高,差异有显著性意义(P<0.05)。AECOPD组不同气流阻塞患者血清8isoPGF2a质量浓度呈线性升高趋势(P<0.05)。COPD全球创议(GOLD)Ⅳ期患者血清8isoPGF2a质量浓度[(8.5±0.97)μg/L]较Ⅰ-Ⅱ期[(6.27±1.38)μg/L]和Ⅲ期[(6.89±1.92)μg/L]患者显著升高(P均<0.05)。12例AECOPD患者治疗后血清8isoPGF2a质量浓度[(4.96±1.49)μg/L]较治疗前[(6.51±1.59)μg/L]显著降低,差异有显著性意义(P<0.05)。结论AECOPD患者血清8isoPGF2a质量浓度显著增高,提示8isoPGF2a可能参与COPD气流阻塞的发病,8isoPGF2a作为一种生化指标监测疾病严重程度和反映COPD急性发作具有一定的临床意义。
Objective To investigate the role and significance of isoprostaglandin (8isoPGF2a) in the pathogenesis of chronic obstructive pulmonary disease (COPD). Methods From September 2005 to September 2006, 61 patients with COPD were enrolled in Department of Respiratory Medicine of Thoracic Hospital of Henan Province, including 38 cases of acute exacerbation (AECOPD) and 23 cases of stable. The other 18 healthy subjects were selected as normal control group , Serum 8isoPGF2a and lung function were measured. Results The serum concentration of 8isoPGF2a in AECOPD group was (6.84 ± 1.70) μg / L, which was significantly higher than that in stable COPD group (5.82 ± 1.72) μg / L and 4.64 ± 1.24 μg / L in healthy control group Sexual significance (P <0.05 and P <0.01). The serum concentration of 8isoPGF2a in AECOPD smoking group was (7.21 ± 1.67) μg / L, which was significantly higher than that in non-smoking group (5.78 ± 1.44) μg / L (P <0.05). In the AECOPD group, the concentration of 8isoPGF2a in serum of patients with different airflow obstruction increased linearly (P <0.05). Serum concentrations of 8isoPGF2a in COPD patients with GOLD stage Ⅳ were significantly higher than those in patients with stage Ⅰ-Ⅱ [(6.27 ± 1.38) μg / L and [Ⅲ] (6.89 ± 1.92) μg / L vs ] Patients were significantly higher (P all <0.05). The serum concentration of 8isoPGF2a in 12 AECOPD patients after treatment was significantly lower than that before treatment [(4.96 ± 1.49) μg / L vs [6.51 ± 1.59 μg / L], P <0.05). Conclusion The serum concentration of 8isoPGF2a in patients with AECOPD is significantly increased, suggesting that 8isoPGF2a may be involved in the obstruction of airflow obstruction in COPD. 8isoPGF2a is a biochemical indicator to monitor the severity of the disease and reflect the acute exacerbation of COPD.