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目的:测定子痫前期患者血清可溶性人类白细胞抗原G(s HLA-G)和白细胞介素-10(IL-10)水平,探讨其在子痫前期发生中的意义。方法:收集子痫前期患者35例、健康孕妇45例和健康未孕妇女38例的血清,酶联免疫吸附法检测s HLA-G和IL-10水平。结果:子痫前期患者血清s HLA-G和IL-10水平均明显低于正常妊娠孕中期组和孕晚期组(均P<0.05);s HLA-G水平高于健康未孕组,IL-10水平低于健康未孕组(均P<0.001)。结论:血清s HLA-G和IL-10水平在子痫前期发生时下降,对其检测有助于预测子痫前期的发生。
Objective: To determine the serum level of soluble human leukocyte antigen G (s HLA-G) and interleukin-10 (IL-10) in patients with preeclampsia and to explore its significance in preeclampsia. Methods: Serum levels of 35 patients with preeclampsia, 45 healthy pregnant women and 38 healthy and nonpregnant women were collected. Serum HLA-G and IL-10 levels were measured by enzyme linked immunosorbent assay. Results: Serum levels of HLA-G and IL-10 in patients with preeclampsia were significantly lower than those in the third trimester and third trimester of pregnancy (all P <0.05) 10 levels were lower than healthy non-pregnant group (all P <0.001). Conclusion: Serum levels of HLA-G and IL-10 are decreased in preeclampsia, which may be helpful to predict preeclampsia.