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目的 :探讨利钾尿肽 (KP)与心钠素摩尔比在急性脑血管疾病 (ACVD)中的意义。方法 :用放射免疫分析方法测定 34例ACVD患者发病不同时期血浆KP和心钠素 (ANP)含量。结果 :急性脑血管疾病患者在发病第 7天血浆KP水平升高 ,病程中ANP含量明显升高 (P <0 0 5 ) ,病程第 1天、第 3天KP与ANP摩尔比显著低于对照组 (P <0 0 5 )。结论 :KP、ANP含量及KP与ANP比例关系的改变在脑血管疾病病理生理中起着一定的作用
Objective: To investigate the significance of kaliuretic peptide (KP) and atrial natriuretic peptide molar ratio in acute cerebrovascular disease (ACVD). Methods: Radioimmunoassay was used to determine the plasma levels of KP and ANP in 34 patients with ACVD at different stages. Results: In the patients with acute cerebrovascular disease, the plasma KP level increased on the 7th day of onset and the ANP content in the course of disease increased significantly (P <0 05). The molar ratio of KP to ANP on the 1st and 3rd day of disease course was significantly lower than that of the control Group (P <0 05). Conclusion: The changes of KP, ANP content and the ratio of KP to ANP play a role in the pathophysiology of cerebrovascular disease