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目的探讨肝滤泡树突细胞肉瘤的病理组织学与免疫组化特点。方法运用组织病理学和免疫组化观察2008年6月首都医科大学附属北京友谊医院普外科诊治的1例肝滤泡树突细胞肉瘤的特点,并复习相关文献对其进行分析。结果肝滤泡树突细胞肉瘤无典型临床症状,无特征性影像学表现,术前难于确诊。CT表现为肝内较大单发肿块。光镜可见:肿瘤细胞呈梭形及卵圆形,细胞间界限不清。免疫组化:肿瘤细胞CD35(+),而CD21(-),CD23(-),S-100(-),ALK基因(-),原位杂交法检测EB病毒(EBER)(-)。结论肝滤泡树突细胞肉瘤是一种少见的低度恶性肿瘤,主要依据组织病理学和免疫组化标记进行诊断。手术切除是主要治疗手段。
Objective To investigate the histopathological and immunohistochemical characteristics of hepatic follicular dendritic cell sarcoma. Methods Histopathology and immunohistochemistry were used to observe the characteristics of a case of hepatofollicular dendritic cell sarcoma diagnosed and treated in Department of General Surgery, Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences in June 2008 and reviewed the relevant literature. Results Hepatic follicular dendritic cell sarcoma had no typical clinical symptoms, no characteristic imaging findings, difficult to diagnose before operation. CT showed a single large intrahepatic lumps. Light microscope shows: Tumor cells were fusiform and oval, cell boundaries unclear. Immunohistochemistry: CD35 (+), CD21 (-), CD23 (-), S-100 (-) and ALK genes (-) were detected by immunohistochemistry. EBV (-) was detected by in situ hybridization. Conclusions Hepatic follicular dendritic cell sarcoma is a rare low-grade malignancy, which is mainly diagnosed by histopathology and immunohistochemistry. Surgical resection is the main treatment.