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目的探讨季节性服用孟鲁司特钠在预防小儿哮喘急性发作中的作用。方法运用随机抽样的方法选取100例哮喘急性发作患儿,依据随机数字表法将患儿分为研究组和对照组各50例。在2月下旬~4月上旬、梅雨季节、9月上旬~10月下旬分别给予对照组患儿布地奈德气雾剂治疗,给予研究组患儿布地奈德气雾剂联合孟鲁司特钠治疗。结果研究组患儿的日间和夜间症状评分及血清总Ig E水平均显著低于对照组,差异有统计学意义(P<0.05);急性加重率16.0%显著低于对照组的34.0%,PEFR、EC显著低于对照组,β-受体激动剂使用次数显著少于对照组,治疗的总有效率96.0%显著高于对照组的74.0%,差异均有统计学意义(P<0.05)。结论季节性服用孟鲁司特钠能够有效预防小儿哮喘急性发作。
Objective To investigate the effect of seasonal montelukast on the prevention of acute asthma in children. Methods A total of 100 children with acute asthma were selected by random sampling method. According to the random number table, the children were divided into study group (50 cases) and control group (50 cases). In late February ~ early April, the rainy season, early September to late October were given to control children with budesonide aerosol treatment, the study group given budesonide aerosol combined with montelukast sodium treatment. Results The scores of daytime and nighttime symptom scores and total serum IgE in study group were significantly lower than those in control group (P <0.05). The acute exacerbation rate was 16.0%, which was significantly lower than that in control group (34.0%), PEFR and EC were significantly lower than those of the control group, and the number of β-agonists was significantly less than that of the control group. The total effective rate was 96.0%, significantly higher than that of the control group (74.0%, P <0.05) . Conclusion Seasonal montelukast sodium can effectively prevent acute exacerbation of pediatric asthma.