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目的观察苦菜总黄酮对实验性肝损伤模型的保护作用。方法 :用四氯化碳致小鼠肝损伤模型 ,以GPT ,GOT为指标 ;用乙醇致小鼠肝损伤模型 ,以GPT ,GSH为指标 ,分析苦菜总黄酮的保肝效应。结果 :苦菜总黄酮能使四氯化碳所致GPT ,GOT下降 ,能使乙醇所致GPT值下降 ,减轻乙醇所致肝脏GSH的耗竭 ,能明显降低四氯化碳所致小鼠肝组织的病理改变。结论 :苦菜总黄酮对四氯化碳、乙醇所致的肝损伤有明显的保护作用 ,可能与苦菜总黄酮减少肝脏GSH耗竭、抑制肝脂质过氧化作用有关
Objective To observe the protective effect of total flavonoids from bitter herbs on experimental liver injury model. Methods: Liver damage model induced by carbon tetrachloride in mice was established. GPT and GOT were used as indexes. Liver injury model induced by ethanol was used. GPT and GSH were used as indexes to analyze the hepatoprotective effect of total flavonoids of bitter herbs. Results: The total flavonoids of bitter herbs could decrease the GPT and GOT caused by carbon tetrachloride, decrease the GPT value induced by ethanol, relieve the exhaustion of hepatic GSH induced by ethanol and significantly reduce the liver tissue of mice induced by carbon tetrachloride Pathological changes. Conclusion: The total flavonoids of bitter herbs have a significant protective effect on liver injury induced by carbon tetrachloride and ethanol, which may be related to the reduction of hepatic GSH depletion and inhibition of hepatic lipid peroxidation by total flavones of bitter herbs