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目的 :探讨慢性乙型肝炎患者拉米呋定治疗前后肝组织学的变化。方法 :随机选择 2 0例慢性乙型肝炎患者 ,口服拉米呋定 ,10 0mg/d× 1y ,治疗前后作肝组织活检、病理检查。结果 :14例患者肝组织炎症明显减轻 ,治疗前后比较 ,呈现显著差异 (P <0 .0 5 )。 2例患者肝组织纤维化减轻 ,治疗前扣比较 ,差异不显著 (P >0 .0 5 )。结论 :拉米夫定可以有效减轻慢性乙型肝炎患者的肝组织炎症 ,但改善肝组织纤维化效果不明显。
Objective: To investigate the changes of liver histology before and after lamivudine treatment in chronic hepatitis B patients. Methods: Twenty patients with chronic hepatitis B were randomly selected and treated with oral lamivudine (100 mg / d × 1y) for liver biopsy and pathological examination before and after treatment. Results: The liver inflammation of 14 patients was significantly relieved, with significant difference before and after treatment (P <0.05). Two cases of liver fibrosis alleviated before treatment compared buckle, the difference was not significant (P> 0.05). Conclusion: Lamivudine can effectively reduce liver inflammation in patients with chronic hepatitis B, but the effect of improving liver fibrosis is not obvious.