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按照祖国医学理论,冠心病主要是由于气滞血淤所致。1971年以来,我们应用中药参三七活血化淤疗法,治疗冠心病心绞痛①,此后国内多个兄弟单位陆续有相同报导②～⑤,确有良效。为了进一步了解其疗效机理,我们用参三七对实验性心肌梗塞的作用进行了研究。 一、材料与方法 成年健康狗共33只,平均体重14公斤(10～18.5公斤),进行冠脉结扎,造成急性心肌梗塞的动物模型。共分两绍:第一组16只,在结扎冠脉手术中及术后应用参三七治疗(下称治疗组)。第二组17只,仅用一般治疗(下称对照组)。两组动物手术前后均用心电图进行观察,部分动物进行了冠脉造影及心肌病理切片检查。 (一)手术方法:全部实验动物手术前两天,按改良的Feola氏法⑥口服利血平0.25毫
In accordance with the motherland medicine theory, coronary heart disease is mainly due to qi stagnation. Since 1971, we apply traditional Chinese medicine reference 37 blood circulation therapy, treatment of angina pectoris ①, since then many domestic units have the same report ② ~ ⑤, indeed good effect. In order to further understand the mechanism of its efficacy, we used the reference Sanqi on the role of experimental myocardial infarction were studied. First, materials and methods A total of 33 adult healthy dogs, the average weight of 14 kg (10 ~ 18.5 kg), coronary artery ligation, resulting in acute myocardial infarction animal model. Divided into two Shao: The first group of 16, coronary artery ligation and postoperative application of reference Sanqi treatment (hereinafter referred to as the treatment group). The second group of 17, only the general treatment (hereinafter referred to as the control group). Two groups of animals before and after surgery were observed with ECG, some animals underwent coronary angiography and myocardial pathology biopsy. (A) surgical methods: all experimental animals two days before surgery, according to the modified Feola’s method ⑥ oral reserpine 0.25 milliliters