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目的:评价放、化疗联合治疗晚期及复发子宫颈癌的远期疗效。方法:选取晚期及复发子宫颈癌病例341例,采用放、化疗联合治疗。放疗采用全盆腔外照射加内照射。总量全盆腔外照射DT30Gy/15次、双侧宫旁DT47.5Gy/23次,内照射DT40~42Gy/6~7次,放疗同期联合化疗,采用CFP方案,共4 ~6个周期。结果:Ⅲ期2年生存率为70.85% ( 158 /223), 5年生存率为50.22% (112 /223);Ⅳ期2年生存率为23 53% (16./68), 5年生存率为14.06% (9 /64);复发病例2年生存率为38 00% (19 /50), 5年生存率为20.00% (10 /50)。2年总生存率为56 59% (193 /341), 5年总生存率为38.41% (131 /341)。结论:放、化疗联合治疗对晚期子宫颈癌是一种有效的治疗手段,患者能耐受,同时也可以改善生活质量。
Objective: To evaluate the long-term efficacy of radiotherapy and chemotherapy in the treatment of advanced and recurrent cervical cancer. Methods: 341 cases of advanced and recurrent cervical cancer were selected and treated with radiotherapy and chemotherapy. Radiotherapy using the whole pelvic external irradiation plus internal irradiation. The total amount of total pelvic radiation DT30Gy / 15 times, bilateral uterine side DT47.5Gy / 23 times, internal irradiation DT40 ~ 42Gy / 6 ~ 7 times, radiotherapy concurrent chemotherapy, using CFP program, a total of 4 to 6 cycles. Results The 2-year survival rate of stage Ⅲ was 70.85% (158/223) and the 5-year survival rate was 50.22% (112/223). The 2-year survival rate of stage Ⅳ was 23 53% (16/68) The rate of 2-year survival was 38 00% (19/50) and 5-year survival rate was 10.00% (9/64). The overall 2-year survival rate was 56 59% (193/341) and the 5-year overall survival rate was 38.41% (131/341). Conclusion: Radiotherapy combined with chemotherapy is an effective treatment for advanced cervical cancer. Patients can tolerate it and improve the quality of life.