论文部分内容阅读
目的考察补充维生素D对轮状病毒感染性腹泻的疗效和对Th1细胞因子的影响。方法收集2013年10月—2015年5月在秦皇岛第一医院儿科收治确诊的轮状病毒(RV)感染性腹泻患儿162例,按照入院顺序随机分为2个组别,对照组80例和观察组82例。观察组在对照组治疗的基础上口服0.25μg/d的1,25(OH)2D3。结果治疗前,两个组别的Th1细胞因子差异无统计学意义(P>0.05),治疗后,两个组别的Th1细胞因子均有不同程度的改善(P<0.05),与对照组比,观察组改善明显(P<0.05)。观察组大便性状改变时间与总疗程均明显缩短(P<0.05)。两组患儿均未发生明显的不良反应。两个组别治疗后有效、无效和总有效例相当(P>0.05),而观察组的显效率(51.2%)高于对照组(35.0%),差异有统计学意义(χ2=4.3,P<0.05)。结论补充维生素D可明显改善对感染性腹泻的症状,可能与降低Th1细胞因子有关。
Objective To investigate the effect of vitamin D supplementation on rotavirus-infected diarrhea and its effect on Th1 cytokines. Methods A total of 162 children with rotavirus (RV) infectious diarrhea diagnosed in pediatric department of Qinhuangdao First Hospital from October 2013 to May 2015 were randomly divided into two groups according to admission sequence, 80 cases in control group Observation group of 82 cases. The observation group was treated with 0.25μg / d 1,25 (OH) 2D3 orally on the basis of the control group. Results Before treatment, there was no significant difference in Th1 cytokines between the two groups (P> 0.05). After treatment, Th1 cytokines in both groups were improved to some extent (P <0.05), compared with the control group , The observation group improved significantly (P <0.05). The observation group stool performance change time and the total course of treatment were significantly shorter (P <0.05). No significant adverse reactions occurred in both groups. The two groups were effective and ineffective after treatment, which was equivalent to the total effective cases (P> 0.05), while the observation group was significantly higher effective rate (51.2%) than the control group (35.0%), the difference was statistically significant (χ2 = 4.3, P <0.05). Conclusion Vitamin D supplementation can significantly improve the symptoms of infectious diarrhea, which may be related to the reduction of Th1 cytokines.