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目的:探讨雌激素联合甲硝唑阴道给药治疗萎缩性阴道炎患者的临床效果。方法:选取我院2013年4月-2014年5月收治的萎缩性阴道炎患者共86例作为研究对象,使用随机数字表法将其分为观察组以及对照组各43例。其中对照组患者均给予甲硝唑治疗,观察组患者则给予雌激素联合甲硝唑治疗,观察两组患者治疗效果,统计两组患者不良反应发生情况,记录两组患者治疗后阴道清洁度例数以及pH<5.0患者数量。结果:观察组患者治疗有效率明显高于对照组,对比差异有统计学意义(P<0.05),观察组患者治疗后阴道清洁度I-II级患者数量以及pH值<5.0患者数量相较于对照组明显更多,两者对比差异有统计学意义(P<0.05),观察组患者不良反应发生率4.7%,对照组患者不良反应发生率14.0%,两者对比差异有统计学意义(P<0.05)。结论:雌激素联合甲硝唑阴道给药治疗萎缩性阴道炎患者具有良好的临床疗效,患者不良反应发生率低,值得临床推广。
Objective: To investigate the clinical effect of vaginal administration of estrogen and metronidazole in patients with atrophic vaginitis. Methods: A total of 86 patients with atrophic vaginitis admitted from April 2013 to May 2014 in our hospital were enrolled in this study. The patients were divided into the observation group and the control group, with 43 cases in each group. The patients in the control group were treated with metronidazole, the patients in the observation group were treated with estrogen combined with metronidazole, the treatment effect was observed in both groups, the incidence of adverse reactions in both groups were recorded, and the vaginal cleanliness after treatment Number and pH <5.0 number of patients. Results: The treatment efficiency in the observation group was significantly higher than that in the control group, the difference was statistically significant (P <0.05), the number of patients with vaginal cleanliness I-II level and the number of patients with pH value less than 5.0 The difference between the two groups was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 4.7% and that in the control group was 14.0%, the difference between the two groups was statistically significant (P <0.05). Conclusion: The vaginal administration of estrogen combined with metronidazole in patients with atrophic vaginitis has a good clinical efficacy, the incidence of adverse reactions in patients with low, worthy of clinical promotion.