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目的分析四联疗法治疗胃十二指肠溃疡的效果。方法选取鹿邑县老君台后街疾病控制中心预防接种门诊2014年1月—2016年1月收治的胃十二指肠溃疡患者200例,按照随机数字表法分为观察组和对照组,各100例。观察组给予黏膜保护剂、抗酸药、抗幽门螺杆菌抗生素、壁细胞受体阻断剂四联疗法治疗,对照组给予黏膜保护剂、抗幽门螺杆菌抗生素治疗,比较两组患者的治疗效果、呕血、呕吐症状消失时间及不良反应情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者呕血、呕吐症状消失时间短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论四联疗法治疗胃十二指肠溃疡具有较好临床效果,安全性高。
Objective To analyze the effect of quadruple therapy on gastroduodenal ulcer. Methods A total of 200 patients with gastroduodenal ulcer admitted from January 2014 to January 2016 in Laojun Taichung Street Center for Disease Control of Luyi County were divided into observation group and control group according to random number table method. 100 cases each. The observation group was treated with mucosal protective agent, antacid, anti-Helicobacter pylori antibiotic and parietal cell blocker quadruple therapy. The control group was treated with mucosal protective agent and anti-Helicobacter pylori antibiotic. The therapeutic effect was compared between the two groups , Vomiting, vomiting, disappearance of symptoms and adverse reactions. Results The total effective rate of the observation group was higher than that of the control group (P <0.05). The vomiting and vomiting disappearance time of the observation group was shorter than that of the control group (P <0.05) The incidence of adverse reactions, the difference was not statistically significant (P> 0.05). Conclusions Quadruple therapy has good clinical efficacy and safety for treating gastroduodenal ulcer.