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将125只大鼠分成5组,分别给予如下处理;①半胱胺,②半胱胺+异搏定,③半胱胺+钙,④钙,⑤对照。在解剖显微镜下评价十二指肠溃疡(DU)发生率和程度,用原子吸收光谱分析法测定钙含量。给果表明:①半胱胺诱发DU的大鼠其十二指肠粘膜钙含量高于对照组,但胃粘膜钙含量和血清钙无变化;③钙阻通剂异搏定能降低半胱胺所致的DU发生率及严重程度并伴有十二指肠粘膜钙含量降低;③钙能增加半胱胺所致DU发生率及严重程度并使十二指肠粘膜钙含量增加;④十二指粘膜钙含量与DU严重程度显著相关。提示十二指肠粘膜钙的聚集在大鼠DU发生中可能起重要作用。
125 rats were divided into 5 groups and given the following treatments; 1 Cysteamine, 2 cysteamine+ verapamil, 3 cysteamine+calcium, 4 calcium, 5 controls. The incidence and degree of duodenal ulcer (DU) were evaluated under a dissecting microscope and the calcium content was determined by atomic absorption spectrometry. The results showed that: 1The cysteamine-induced DU rats had higher duodenal mucosal calcium content than the control group, but there was no change in the gastric mucosal calcium content and serum calcium;3 The calcium barrier agent verapamil reduced the cysteamine The resulting incidence and severity of DU were accompanied by a decrease in the calcium content of the duodenal mucosa. 3Calcium increased the incidence and severity of DU caused by cysteamine and increased the calcium content of duodenal mucosa. The mucosal calcium content was significantly associated with DU severity. It is suggested that calcium accumulation in the duodenal mucosa may play an important role in the development of rat DU.