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本文采用双抗体夹心ELISA法分别对喘息性支气管炎、支气管哮喘患儿进行了血清可溶性白细胞介素Ⅱ受体(sIL-2R)水平测定,并与支气管肺炎患儿和健康儿童相比较。结果表明:喘息性支气管炎和支气管哮喘患儿在疾病发作期和恢复期血清sIL-2R水平较支气管肺炎患儿以及健康儿童皆明显升高(P<0.01)。而支气管肺炎患儿的血清sIL-2R水平在疾病过程中则维持正常水平,与健康儿童比较P>0.05。血清sIL-2R水平的变化提示喘息性交气管炎和支气管哮喘患儿有共同的免疫功能障碍,与患儿喘鸣发作密切相关。
In this study, serum IL-2R levels were measured in patients with asthmatic bronchitis and bronchial asthma by double antibody sandwich ELISA and compared with those of children with bronchial pneumonia and healthy children. The results showed that children with asthmatic bronchitis and bronchial asthma had significantly higher serum sIL-2R levels than those with bronchopneumonia and healthy children during the onset and convalescent periods (P <0.01). Serum sIL-2R levels in children with bronchopneumonia maintained normal levels during the disease, compared with healthy children (P> 0.05). Changes in serum sIL-2R levels suggest that asthmatic bronchitis and bronchial asthma in children with common immune dysfunction, and children with wheezing is closely related.