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目的探讨空勤人员糖尿病前期的干预措施,以期尽快恢复患者血糖水平,尽早恢复执勤。方法选取2010年1月至2013年12月空勤人员年度体检时发现的62例糖尿病前期患者,采用随机数字法分为两组,对照组患者口服盐酸二甲双胍片,随餐服用;观察组患者口服阿卡波糖,随餐嚼服,同时给予两组患者心理辅导、饮食及运动指导,患者均持续治疗12周,比较两组患者血糖水平恢复正常逆转率、不良反应发生率、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹血脂水平[血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)],以及尿酸(UA)含量变化情况。结果两组患者治疗前FPG、2 h PG、TC、TG、HDL-C、LDL-C以及UA水平差异均无统计学意义(P>0.05),治疗后HDL-C、LDL-C、UA水平较治疗前无明显变化(P>0.05);FPG、2 h PG、TC、TG水平均较治疗前明显降低,差异有统计学意义(P<0.05),观察组患者FPG、2 h PG、TC、TG水平虽较对照组无明显变化(P>0.05),但观察组患者FPG、2 h PG、TC、TG水平更接近于正常人;观察组血糖水平恢复正常逆转率为67.7%,略高于对照组的58.1%,差异无统计学意义(P>0.05);两组各有1例患者出现腹胀、腹泻以及食欲不振等不良反应,均自行缓解。结论口服阿卡波糖片,辅以心理辅导、饮食及运动指导能有效控制空勤人员糖尿病前期患者的血糖水平,降低糖尿病的发生率。
Objective To explore the pre-diabetes interventions of flight attendants so as to restore the blood glucose level of patients as soon as possible and resume their duty as soon as possible. Methods Sixty-two patients with pre-diabetes who were found on the aircrew’s physical exam from January 2010 to December 2013 were randomly divided into two groups. Patients in the control group were treated with metformin hydrochloride tablets orally, and the patients in the observation group were orally taken orally At the same time, two groups of patients were given psychological counseling, diet and exercise instruction. All patients were treated for 12 weeks. The normal rate of return of blood glucose, incidence of adverse reactions, fasting blood glucose (FPG) (2 h PG), fasting blood lipid (TC, TG, HDL-C, LDL-C )], And uric acid (UA) content changes. Results There was no significant difference in the levels of FPG, 2 h PG, TC, TG, HDL-C, LDL-C and UA between the two groups before treatment (P> 0.05) FPG, 2 h PG, TC, TG levels were significantly lower than before treatment, the difference was statistically significant (P <0.05), the observation group FPG, 2 h PG, TC (P> 0.05). However, the levels of FPG, 2 h PG, TC and TG in the observation group were more similar to those in the normal control group. The blood glucose level returned to normal in the observation group with a normal rate of 67.7% There was no significant difference in the control group (58.1%) (P> 0.05). One patient in each group had adverse reactions such as abdominal distension, diarrhea and loss of appetite. Conclusion oral acarbose tablets, supplemented by psychological counseling, diet and exercise guidance can effectively control the aircrew pre-diabetes patients with blood glucose levels, reduce the incidence of diabetes.