越来越多的证据显示,高同型半胱氨酸血症不仅是脑血管病的高危因素,而且还与Alzheimer病、Parkinson病、痴呆、认知障碍、抑郁症和精神分裂症等多种神经变性疾病和精神疾病密切相关。同型半胱氨酸的神经毒性机制尚不完全清楚,可能包括通过激活细胞外信号调节激酶、过度激活谷氨酸受体、参与氧化应激反应、影响甲基化过程和损伤DNA等。 There is growing evidence that hyperhomocysteinemia is not only a risk factor for cerebrovascular disease but also is associated with a variety of nerves such as Alzheimer’s disease, Parkinson’s disease, dementia, cognitive disorders, depression and schizophrenia Degeneration and mental illness are closely related. The mechanism of homocysteine ​​neurotoxicity is not completely understood, which may include activation of extracellular signal-regulated kinase, overexpression of glutamate receptors, involvement in oxidative stress, methylation and DNA damage.