姊妹染色单体互换技术作为检测诱变剂和致癌剂的手段已被肯定。目前报道多为离体试验,因其较易成功。但离体试验有一定的局限性,难以完全反应体内代谢情况。体内试验比体外试验优越,所需动物少,用2～4只即可,但活体肝脏可使SCE法所需的5-澳脱氧尿嘧啶核苷(BrdU)迅速脱溴,而致实验失败。因此活体SCE法至今仍处于不断探 Sister chromatid exchange techniques as a means of detecting mutagens and carcinogens have been identified. Currently reported mostly in vitro tests, because of its easier success. However, in vitro tests have some limitations, it is difficult to fully reflect the body’s metabolism. In vivo tests superior to in vitro experiments, the required animal less, with 2 to 4 can be, but the living liver SCE method can be required 5 - Odeoxyuridine (BrdU) debromination, and the experiment failed. So in vivo SCE method is still in continuous exploration