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目的 探讨老年人脑梗塞脑脊液 (CSF)及血清中肿瘤坏死因子 (TNF)的变化及其与年龄的关系。 方法 用ELISA(双抗体夹心 )方法对 45例老年脑梗塞患者CSF及血清TNF α进行检测 ,并与 31例中青年脑梗塞和 30例健康人进行比较。 结果 老年组CSF中TNF α含量明显高于对照组 (P <0 0 1)及中青年组 (P <0 0 1) ;血清TNF α含量中青年组与对照组比较无明显差异 (P >0 0 5 ) ,老年组明显增高 (P <0 0 1) ;老年组CSF中TNF α含量与周围血白细胞数及年龄有非常显著相关性 (r值分别为 0 5 0 47、0 6 2 0 5 ,P <0 0 1)。 结论 TNF α是老年脑梗塞的致病因子和加重缺血性脑损伤的重要因素
Objective To investigate the changes of cerebral infarction cerebrospinal fluid (CSF) and serum tumor necrosis factor (TNF) in elderly patients and its relationship with age. Methods CSF and serum TNFα in 45 elderly patients with cerebral infarction were detected by ELISA (double antibody sandwich method) and compared with 31 cases of middle-aged and young cerebral infarction and 30 healthy people. Results Compared with control group (P <0.01) and middle-aged and young group (P <0.01), TNFα in CSF of elderly group was significantly higher than that of control group (P> 0) (P <0.01). There was a significant correlation between TNFα level in peripheral CSF and the number and age of peripheral blood leukocytes (r = 0 5047, 0 6 2 0 5 , P <0 0 1). Conclusion TNF α is a causative factor in elderly cerebral infarction and an important factor in aggravating ischemic brain injury