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本文应用高效液相色谱法测定了8名健康受试者自身交叉服用炎痛喜康普通片与控释片(分别服用单剂量20mg)后的血药浓度。用非线性最小二乘模型嵌合的计算机程序对数据进行处理,表明该药在体内为一室模型,并求得各项参数如下:普通片,k_a=1.568h~(-1),k=0.0191h~(-1),V=7.9201,t_(max)=4.4h,C_(max)=2.502μg/ml,AUC=150.04h·μg/ml;控释片,ka=0.185h~(-1),k=0.0223h~(-1),V=7.3561,t_(max)=15.3h,C_(max)=2.048μg/ml,AUC=129.63h·μg/ml.
In this paper, eight healthy volunteers were tested for their blood levels after oral administration of Yan Tong Xi Kang ordinary tablets and controlled release tablets (taking a single dose of 20 mg respectively) by high performance liquid chromatography. The data were processed by a computer program fitting with a nonlinear least square model, indicating that the drug is a one-compartment model in vivo and the parameters are as follows: normal tablet, k_a = 1.568h -1, k = 0.0191h -1, V = 7.9201, t max = 4.4h, C max = 2.502μg / ml, AUC = 150.04h · μg / ml; controlled release tablets, ka = 0.185h ~ 1, k = 0.0223 h -1, V = 7.3561, t max = 15.3 h, C max = 2.048 μg / ml and AUC = 129.63 h · μg / ml.