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血管内皮生长因子(vascular endothelial growth factor,VEGF)及其受体是血管新生的正调控因子,最近发现VEGF在多种恶性血液病细胞表达升高,是许多恶性血液病细胞生长转移的重要刺激因子之一,抑制VEGF及其受体的产生为治疗某些恶性血液病治疗新策略。
Vascular endothelial growth factor (VEGF) and its receptor are positive regulators of angiogenesis. Recently, VEGF has been found to be expressed in many malignant hematological malignancies and is an important stimulator of the growth and metastasis of many hematological malignancies First, the inhibition of VEGF and its receptor production for the treatment of certain new hematologic malignancy treatment strategy.