目的探讨彩色多普勒超声探测子宫颈癌组织的血流信号和免疫组化法检测的肿瘤内微血管密度(MVD)的相互关联及其与宫颈癌临床病理的关系。方法收集临床资料,采用彩色多普勒超声探测38例子宫颈癌和45例正常宫颈组织内血流信号,计测阻力指数(RI);采用免疫组化技术检测肿瘤MVD。结果子宫颈癌患者的MVD显著高于正常宫颈组织(P<0.01);子宫颈癌组织内血流RI值显著低于正常宫颈组织(P<0.01)。宫颈癌肿瘤组织内血流RI值和MVD与组织学分级、临床分期有关(P均<0.05),而与淋巴结转移、组织学分型无关(P均>0.05)。子宫颈癌肿瘤组织内血流RI值与免疫组化检测的肿瘤MVD呈负相关(r=-0.489,P=0.018)。结论彩色多普勒超声检测子宫颈癌血流RI值与免疫组化检测肿瘤MVD从不同角度反映子宫颈癌的血管生成情况,有利于对子宫颈癌血管生成及预后的评价。 Objective To explore the correlation between color Doppler flow imaging and cervical intraepithelial microvessel density (MVD) detected by immunohistochemistry and its relationship with clinicopathological features of cervical cancer. Methods The clinical data were collected. The flow signals in 38 cases of cervical cancer and 45 cases of normal cervical tissue were detected by color Doppler ultrasound. The resistance index (RI) was measured. The tumor MVD was detected by immunohistochemistry. Results The MVD of cervical cancer patients was significantly higher than that of normal cervical tissues (P <0.01). The RI of cervical cancer tissues was significantly lower than that of normal cervical tissues (P <0.01). The RI value and MVD in cervical cancer tissue were correlated with histological grade and clinical stage (all P <0.05), but not with lymph node metastasis and histological type (all P> 0.05). The RI of blood flow in cervical cancer tissues was inversely correlated with the tumor MVD detected by immunohistochemistry (r = -0.489, P = 0.018). Conclusion The color Doppler ultrasonography detection of cervical cancer RI and immunohistochemical detection of MVD from different angles reflect the angiogenesis of cervical cancer is conducive to the evaluation of angiogenesis and prognosis of cervical cancer.