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目的:研究难治性癫癎与血清神经节苷脂GM1抗体(GM1-A)及谷氨酸脱羧酶抗体(GAD-A)水平的关系,探讨其免疫学机制。方法:应用酶联免疫吸附法(ELISA)测定60例难治性癫癎(IE组)和60例非难治性癫癎(NE组)患者及60例健康对照组(HC组)血清GM1-A和GAD-A水平。结果:GM1-A和GAD-A水平,IE组与HC组和NE组比较显著增加(P<0.05),NE组与HC组比较差异无显著性意义。结论:GM1-A和GAD-A水平与难治性癫癎关系密切,提示难治性癫癎与自身免疫有关。
Objective: To investigate the relationship between intractable epilepsy and serum GM1-GM1 antibody and glutamic acid decarboxylase antibody (GAD-A) levels and to explore its immunological mechanism. Methods: The serum levels of GM1-A in 60 patients with refractory epilepsy (IE) and 60 patients with non-refractory epilepsy (NE) and 60 healthy controls (HC) were measured by enzyme-linked immunosorbent assay And GAD-A levels. Results: The levels of GM1-A and GAD-A in IE group were significantly higher than those in HC group and NE group (P <0.05). There was no significant difference between NE group and HC group. Conclusion: The levels of GM1-A and GAD-A are closely related to refractory epilepsy, suggesting that refractory epilepsy is associated with autoimmunity.