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在Pd(PPh_3)_4/CuI催化下和使用1mol的NEt_3作碱和THF作溶剂,(Z)-3-碘-3-三氟甲基-1-芳基烯丙醇(1)与末端炔烃(3)反应得到正常的偶联产物5。当以NEt_3作碱和溶剂,Pd(PPh_3)_4/CuI催化1与3的交叉偶联反应生成化合物4。4为正常偶联化合物5在NEt_3存在下双键发生重排反应的产物。
(Z) -3-iodo-3-trifluoromethyl-1-arylalcohol (1) and terminal alkyne under the catalysis of Pd (PPh_3) _4 / CuI and using 1 mol of NEt_3 as the base and THF Hydrocarbon (3) reacts to give the normal coupled product 5. When NEt_3 is used as a base and a solvent, Pd (PPh_3) _4 / CuI catalyzes the cross coupling reaction of 1 and 3 to form compound 4.4, which is the product of double bond rearrangement of normal coupling compound 5 in the presence of NEt_3.