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青霉烷砜／头孢哌酮是β－内酰胺酶抑制剂（青霉烷砜）与头孢哌酮联合的新型头孢菌素，具有很广的抗菌谱与很高的抗菌活性，尤其是对产生β－内酰胺酶细菌的作用。本研究用青霉烷砜／头孢哌酮２．０ｇ，１２ｈ一次静点，与头孢噻肟２．０－４．０ｇ，８－１２ｈ一次静点，疗程７－１４ｄ治疗急性下呼吸道细菌感染５０对，取得了良好的临床及细菌学疗效。两药临床有效率分别为８８％，８６％，细菌清除率为８６％，８２％，不良反应发生率８％，１０％，主要为消化道症状及轻度转氨酶升高。
Penicillin sulfone / cefoperazone is a new cephalosporin combined with cefoperazone, a β-lactamase inhibitor (penicillin sulfone), has a broad antibacterial spectrum and high antibacterial activity, especially for the production of The role of β-lactamase bacteria. In this study, penicillin sulfone / cefoperazone 2.0g, 12h a static point, and cefotaxime 2.0-4.0g, 8-12h a static point, the treatment of 7-14d acute lower respiratory tract bacterial infection 50 Right, made a good clinical and bacteriological efficacy. The clinical effective rates of the two drugs were 88% and 86% respectively, the bacterial clearance rate was 86% and 82%, and the adverse reaction rate was 8% and 10% respectively. The main symptoms were gastrointestinal symptoms and mild transaminase.