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目的：研究 TM_Gp 方案（胸腺五肽；甲地孕酮；吉西他滨；顺铂）与 Gp 方案（吉西他滨；顺铂）对初治Ⅲ_Ⅳ期 NSCLC（非小细胞肺癌）患者的疗效、毒性反应及生活质量的改善情况。方法所有选取的病例按肿瘤多学科联合会诊制度及流程确定。A 组（33例）接受 TM_Gp 方案治疗；B 组（35例）接受 Gp 方案治疗。2组均以4周为1周期，重复3个周期。客观疗效与毒性反应按市、县级医院常见肿瘤规范化诊疗指南（试行）》标准进行评价，生活质量根据临床受益疗效来评价。结果客观疗效（CR ﹢ pR）：A 组为27,3％；B 组为22,9％（p ＞0,05）；中位生存期：A组32周，B 组27周（p ＜0,01）；白细胞减少及恶心呕吐反应 B 组均较 A 组明显（p ＜0,01）；短暂性寒战、发热症状多见于 A 组（p ＜0,01）；2组均未发现其他严重的不良反应。A 组行为状态阳性率45,4％，B 组行为状态阳性率20,0％（p ＜0,05）。A 组体质量阳性率30,3％；B 组体质量阳性率11,4％（p ＜0,05）。A 组临床受益疗效高于 B 组（p ＜0,05）。结论 TM_Gp 方案与 Gp 方案客观疗效无明显差异性；TM_Gp 联合方案中位生存期长，不良反应小，生活质量改善明显。“,”Objective To study the efficacy,reactions of toxic and improvement of life quality of TM_Gp scheme (thymopentin megestrol;megestrol;gemcitabine;and cisplatin)and Gp(gemcitabine and cisplatin)on initial Ⅲ _ Ⅳ NSCLC (non_small cell lung cancer)patients, Methods All cases were collected according to tumor multidisciplinary joint consulta_tion system and process, Group A(n = 33)received TM_Gp solution for treatment;the Group B(n = 35)received Gp solution for treatment, Both groups were treated with 4 weeks as 1 cycle,with repeating 3 cycles, Objective curative effect and toxicity were evaluated according to the municipal,county_level hospitals common tumor standardized guidelines(try out)standard, The quality of life was assessed according to the clinical benefit response, Results The objective curative effect(CR ﹢ pR):group A was 27, 3% ;group B was 22, 9%(p > 0, 05);The median survival:group A was 32 weeks,while the group B was 27 weeks(p < 0, 01);In the matter of leukopenia,nausea and vomiting response,the group A was better than group B significant (p < 0, 01);The transient chills,fever symptoms were more common in the A group(p < 0, 01);Both groups were not found other serious toxicity reaction, The behavior state positive rate of group A was 45, 4% ,while the group B was 20, 0% ;(p <0, 05), The body weight positive rate of group A were 30, 3% ,while the group B was 11, 4% ;(p < 0, 05), The clinical benefit response of group was higher than group B(p < 0, 05), Conclusion There is no obvious difference in curative effect between TM_Gp solutions andd Gp;The median survival period of TM_Gp is long,with smaller side reaction,and the quality of life of which improved significantly.