The structural vibration and the sound radiation induced by the flow over a cavity on a hydrofoil are investigated experimentally and numerically. The large eddy simulation (LES) is adopted to calculate the flow field and the pressure fluctuation characteristics. A coupled finite element method/boundary element method approach is used to analyze the hydrofoil vibration and the structure-be noise. The flow noise is calculated using an acoustic analogy by considering the surface pressure fluctuations as the dipole sources. A hollow hydrofoil with an orifice supported by four cylinder rods is constructed for the experiments. Modal tests are performed to obtain the natural frequencies of the hydrofoil in air and water. The vibro-acoustic experiments are carried out in the water tunnel at various free stream velocities with the orifice open and closed. A pressure transducer is used to measure the pressure fluctuations behind the downstream edge of the orifice. The triaxial accelerometers mounted on the side walls are used to measure the vibrational response of the hydrofoil. Furthermore, a hydrophone located in a box, filled with water is used to measure the sound radiation. The structure-be noise and the flow noise are identified by their frequency properties. Reasonable agreements are observed between the numerical predictions and the experimental measurements.