论文部分内容阅读
Ｗｉｓｔａｒ大白鼠腹腔注射Ｅ．ｃｏｌｉ内毒素纯制剂（２ｍｇ／Ｋｇ体重），１２小时后，其肝脏线粒体琥珀酸脱氢酶（ＳＤＨ）活力显著降低（Ｐ＜０．０１），胞浆还原型谷胱甘肽（ＧＳＨ）水平明显下降（Ｐ＜０．０５）。线粒体内丙二醛类脂质过氧化物（ＬＰＯ）含量和超氧化物歧化酶（ＳＯＤ）活力显著增加（Ｐ均小于０．０１）。线粒体膜脂质成分ＰＥ、ＰＳ、ＰＣ含量均明显下降，ｌｙＳｏ－ＰＣ显著增加。组织学和电镜观察表现为一定程度的肝细胞损伤。用地塞米松按４ｍｇ／Ｋｇ体重，分别在内毒素处理的同时、２小时后４小时后注射。结果显示：同时注射和２小时后注射组，上述各项生化指标与内毒素组比较均有显著改善，而４小时后注射组无明显改善。
Wistar rats were injected intraperitoneally with E. After 2 hours, the activity of mitochondrial succinate dehydrogenase (SDH) in liver was significantly decreased (P <0.01), and the level of cytosolic reduced glutathione (GSH) Decreased significantly (P <0.05). The content of malondialdehyde (LPO) and superoxide dismutase (SOD) in mitochondria increased significantly (P <0.01). Mitochondrial membrane lipid components PE, PS, PC were significantly decreased, lySo-PC increased significantly. Histology and electron microscopy showed some degree of hepatocellular injury. With dexamethasone by 4mg / Kg body weight, respectively, in the endotoxin treatment at the same time, 2 hours after 4 hours after injection. The results showed that: the simultaneous injection and 2 hours after injection group, the above biochemical indicators and endotoxin group were significantly improved compared with 4 hours after injection group no significant improvement.