论文部分内容阅读
目的：探讨庚型肝炎病毒（ＨＧＶ）在维持性血液透析（ＨＤ）患者中的流行情况及感染相关因素。方法：应用半套式ＲＴ－ＰＣＲ方法检测１０２名ＨＤ患者血清ＨＧＶ，并分析其与透析时间、输血、肝功能损害及ＨＣＶ、ＨＢＶ感染的关系。结果：ＨＤ患者ＨＧＶ感染率达１６％，远高于正常对照人群的２．５％，（Ｐ＜０．０１）。ＨＧＶ感染相关因素分析提示：随着透析时间的延长，输血次数的增加，ＨＧＶ感染率明显增高；ＨＧＶ伴发ＨＣＶ感染的发病率明显增高，达３８％，并增加了肝功能损害的机率，（Ｐ＜０．０５）。结论：ＨＤ患者是ＨＧＶ感染的高危人群，其高发生率可能与输血有关，ＨＧＶ多与ＨＣＶ同时感染，并可能诱发肝损害。
Objective: To investigate the prevalence of hepatitis G virus (HGV) in patients with maintenance hemodialysis (HD) and the related factors of infection. Methods: The serum HGV levels of 102 patients with HD were detected by semi-set RT-PCR. The relationship between HGV and dialysis time, blood transfusion, liver damage and HCV and HBV infection were analyzed. Results: The prevalence of HGV infection in HD patients was 16%, much higher than that of controls (2.5%) (P <0.01). HGV infection-related factors suggest that: with the extension of dialysis time, the increase in the number of transfusions, HGV infection was significantly increased; HGV associated with HCV infection was significantly increased, up to 38%, and increased the chance of liver damage, ( P <0.05). Conclusion: HD patients are high risk of HGV infection. The high incidence of HD may be related to blood transfusion. HGV mostly co-infected with HCV and may induce liver damage.