细菌 DNA因含有非甲基化胞嘧啶 -鸟嘌呤双核苷酸 (Cp G)基序而具有直接的免疫刺激作用。合成寡脱氧核苷酸 (ODN)带有 1个或数个这样的基序 ,因此亦具有免疫刺激性。为此作者对 Cp G ODN作为粘膜免疫佐剂的可能性进行了研究作者以 HBs Ag为抗原 ,以霍乱毒素(CT)和 Cp G ODN为佐 Bacterial DNA has a direct immunostimulatory effect due to the unmethylated cytosine-guanine dinucleotide (CpG) motif. Synthetic oligodeoxynucleotides (ODNs) carry one or more of these motifs and are therefore also immunostimulatory. To this end the authors of the Cp G ODN as mucosal immune adjuvant possibilities were studied with HBsAg as antigen, cholera toxin (CT) and Cp G ODN