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(一)本文报告了药物对于血吸虫病病兔及正常家兔的红血球沉降率,血浆纤维蛋白,丙种球蛋白,凝血酶元时值及体重的影响。(二)酒石酸锑钾的治疗,无论在家兔患病的早期或后期,均可抑制其血沉的加速,而以早期治疗的抑制作用更为显著。同时这个抑制血沉的作用与治疗后的成虫发育率是符合的。因此利用这种方法,可以考虑作为研究一些治疗血吸虫病药物的疗效指标。(三)酒石酸锑钾及士的宁本身对正常家兔的血沉并不引起改变,士的宁对于病兔的血沉也无明显作用,但士的宁可以影响酒石酸锑钾对病兔血沉的抑制作用。 (四)半疗程剂量酒石酸锑钾并用士的宁之疗效较单独应用半疗程剂量酒石酸锑钾者为高(10—20%),而单独应用士的宁并无任何疗效,轻度激动量士的宁也不增加酒石酸锑钾的毒性。(五)酒石酸锑钾的治疗剂量对于正常家兔之血浆纤维蛋白元无明显影响,但能使病兔增高之血浆纤维蛋白元回复正常。(六)酒石酸锑钾的治疗可以使病兔的丙种球蛋白在一定时期内保持在接近正常值范围内,这一抑制作用与感染对照组相比,甚为明显,而氨苯氧烷却无此作用,这一点可能与疗效是有关系的。(七)酒石酸锑钾治疗后的病兔之体重较感染对照组病兔显著增高,而经氨苯氧烷治疗后之病兔,其体重仍日见减轻。(八)氨苯氧烷有较高的毒性,但疗效甚低,它对病兔的血沉及纤维蛋白元所出现的抑制作用,究竟属于对血吸虫或其虫卵的作用,抑系对于病兔机体的毒性作用,目前还不能肯定。
(1) The paper reports the effects of drugs on erythrocyte sedimentation rate, plasma fibrin, gamma globulin, thrombin time and body weight of schistosomiasis sick rabbits and normal rabbits. (B) the antimony potassium tartrate treatment, whether early or late disease in rabbits, can inhibit the acceleration of erythrocyte sedimentation rate, and the inhibition of early treatment is more significant. At the same time, the role of inhibition of erythrocyte sedimentation rate after treatment and the rate of development is consistent. Therefore, the use of this method can be considered as a study of some therapeutic efficacy of schistosomiasis drugs. (C) antimony potassium tartrate and strychnine itself does not cause changes in the normal rabbit erythrocyte sedimentation rate, strychnine for the rabbit erythrocyte sedimentation rate also had no significant effect, but strychnine can affect the inhibition of antimony Sulfate anti-rabbit erythrocyte sedimentation rate effect. (D) the dose of antimony potassium tartrate combined with strychnine half a course of treatment compared with the single application of anti-potassium tartrate dose of treatment was high (10-20%), while the separate application of strychnine without any effect, mild excitement Ning does not increase the toxicity of antimony potassium tartrate. (E) The antimony potassium tartrate treatment dose for normal rabbit plasma fibrinogen no significant effect, but can make sick rabbits increased plasma fibrinogen returned to normal. (F) antimony potassium tartrate treatment can make sick rabbit gamma globulin within a certain period of time to maintain close to normal range, the inhibitory effect compared with the infected control group, is very obvious, and no ammonia transalkanal This effect, this may be related to the efficacy. (7) The body weight of rabbits after treatment with antimony potassium tartrate was significantly higher than that of infected rabbits, while the weight of rabbits after treatment with amnofluran was still reduced. (8) Ammonia has high toxicity, but the curative effect is very low. It inhibits the erythrocyte sedimentation rate and fibrin of sick rabbits, which belongs to the effect on schistosome or its eggs, The toxic effects of the body, is still not sure.