目的探讨血清C反应蛋白(CRP)、高敏C反应蛋白(sCRP)浓度对诊断新生儿败血症的敏感性和特异性,为临床提供准确快速的诊断依据。方法用比浊法测定新生儿败血症患者的CRP、sCRP浓度,并与WBC计数进行比较。结果 CRP、sCRP对诊断新生儿败血症的敏感性均高于WBC计数,3个指标中敏感性以sCRP最高;特异性、阳性预测值以CRP最高;阴性预测值和约登指数CRP、sCRP两者相差无几。结论 C反应蛋白浓度检测对新生儿败血症的早期诊断有一定价值。 Objective To investigate the sensitivity and specificity of serum C-reactive protein (CRP) and high-sensitivity C-reactive protein (sCRP) in the diagnosis of neonatal sepsis and to provide an accurate and rapid diagnostic basis for clinical diagnosis. Methods The turbidimetric method was used to determine CRP and sCRP levels in neonates with septicemia and compared with WBC count. Results The sensitivities of CRP and sCRP to the diagnosis of neonatal sepsis were higher than those of WBC count. The sensitivity of the three indexes was the highest, the specificity and positive predictive value were the highest, while the negative predictive value and Youden index were both different Not much. Conclusion The detection of C-reactive protein has some value in the early diagnosis of neonatal sepsis.