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一、前言DNA是遗传物质的主要化学成分,也认为是致癌和诱变物质的主要靶目标,故任何DNA方面的变化也就预示看触及到遗传物质的某些影响的发生,因此,围绕着以DNA变化为终点的测定方法也就应需而生,且发展较快。测定DNA变化的方法不外乎两大类,即围绕DNA的损伤和修复或寓意其间。现将DNA损伤的性质;修复的方式及有关测定方法简要、回顾并综合一表如下。化学性致癌物以引起碱基损伤占优势,但也可引起不同比例的其他类损伤,大多数化学致癌物与紫外线所引起的损伤相类似,不同于X射线引起的损伤。紫外线为核酸和
I. INTRODUCTION DNA is the main chemical component of genetic material and is also considered as the main target of carcinogens and mutagens. Therefore, any change in DNA indicates the occurrence of some impact on the genetic material. Therefore, The determination of the end of the DNA change method should also be born, and the rapid development. There are just about two ways to measure changes in DNA, around DNA damage and repair or to implicate it. Now the nature of DNA damage; repair methods and the determination of a brief, review and synthesis of a table below. Chemical carcinogens are predominant to cause base damage, but they can also cause different proportions of other types of damage. Most chemical carcinogens are similar to those caused by UV light, unlike X-ray-induced damage. UV is nucleic acid and