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目的:分析胎膜早破(premature rupture of memberane,PROM)所致孕妇绒毛膜羊膜炎的细菌培养及药敏结果,探讨胎膜早破引起的绒毛膜羊膜炎主要致病菌的病原学特征,为围产期感染用药提供科学依据。方法:对2011年6月至2013年9月在我院分娩的597例破膜时间大于24小时的PROM孕妇的胎膜进行细菌培养及药敏试验。结果:597例破膜时间大于24小时的PROM孕妇的胎膜细菌培养中,86例培养阳性,阳性率为14.41%;培养阳性病例中革兰氏阴性杆菌占73.26%(63/86),革兰氏阳性菌球菌占34.88%(30/86),培养最多的菌种是大肠埃希菌,占60.47%(52/86)。革兰氏阴性杆菌对亚胺培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、庆大霉素、头孢西丁、左氧氟沙星敏感;革兰氏阳性球菌对亚胺培南、丁胺卡那、哌拉西林/他唑巴坦、替考拉宁、万古霉素、利奈唑胺、庆大霉素、头孢西丁、左氧氟沙星敏感。结论:革兰氏阴性杆菌是PROM相关的绒毛膜羊膜炎的主要致病菌,应根据病原学特征合理应用抗生素。
OBJECTIVE: To analyze the bacterial culture and drug susceptibility of chorioamnionitis in pregnant women induced by premature rupture of memberane (PROM), and to explore the etiological characteristics of the main pathogens of chorioamnionitis caused by premature rupture of membrane (PROM) Provide a scientific basis for perinatal infection medication. Methods: The bacterial culture and drug sensitivity test of 597 PROM pregnant women with membranes ruptured for more than 24 hours from June 2011 to September 2013 were performed in our hospital. Results: Among the 597 PROM pregnant women whose membrane rupture time was longer than 24 hours, 86 cases were positive for culture, the positive rate was 14.41%. Gram-negative bacilli accounted for 73.26% (63/86) Strains of Lancoccus positive accounted for 34.88% (30/86), the most cultured strains of Escherichia coli, accounting for 60.47% (52/86). Gram-negative bacilli were sensitive to imipenem, piperacillin / tazobactam, cefoperazone / sulbactam, gentamycin, cefoxitin and levofloxacin; Gram-positive cocci were sensitive to imipenem , Amikacin, piperacillin / tazobactam, teicoplanin, vancomycin, linezolid, gentamicin, cefoxitin, and levofloxacin. CONCLUSIONS: Gram-negative bacilli are the major pathogens of PROM-associated chorioamnionitis. Antibiotics should be rationally applied according to the etiological characteristics.