目的:提高临床医生对Ménétriér病的诊断与鉴别诊断的能力。方法:回顾性分析我院收治并确诊的3例Ménétriér病病人的诊治经过,剖析误诊因素。结果:2例术前诊断错误,术后病理确诊;1例由协和医院确诊。Ménétriér病在黏膜征象、低蛋白血症和病理学改变三方面具有特征性改变,多次多点胃黏膜全层活检是确诊本病的关键。结论:临床医生通过加强对Ménétriér病的认识和提高相关的鉴别诊断的能力,能够早期地诊断和治疗该病。 Objective: To improve clinicians ability to diagnose and differentiate Ménétriér’s disease. Methods: The diagnosis and treatment of 3 Ménétriér patients admitted and diagnosed in our hospital were retrospectively analyzed to analyze the misdiagnosis factors. Results: Two cases were wrongly diagnosed preoperatively and confirmed postoperatively. One case was diagnosed by Union Hospital. Ménétriér disease has characteristic changes in mucosal signs, hypoproteinemia and pathological changes in three aspects, multiple gastric mucosal multi-level biopsy is the key to diagnosis of the disease. Conclusion: Clinicians can diagnose and treat the disease early by strengthening their understanding of Ménétriér disease and by improving their ability to make differential diagnosis.