引言肿瘤细胞凋亡的失控与肿瘤组织的生长关系密切．近年来，关于肿瘤细胞凋亡基因的异常表达与肿瘤细胞凋亡关系的研究已为肿瘤分子生物学研究的热点．bclZ和bax是一对调控细胞凋亡的重要基因．研究发现bclZ和bax间的比率关系决定细胞的凋亡状态［’‘．fos基因是从两种小鼠的 Introduction The loss of control of tumor cell apoptosis is closely related to the growth of tumor tissue. In recent years, the study of the relationship between the abnormal expression of tumor cell apoptosis gene and tumor cell apoptosis has become a hot topic in the research of tumor molecular biology. bclZ and bax are important genes regulating apoptosis. The study found that the ratio between bclZ and bax determines the apoptotic state of cells [’‘. Fos gene is from two kinds of mice