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目的:探讨不同剂量莫西沙星联合抗结核综合治疗对结核性脑膜炎预后及患者生活质量的影响。方法:将90例结核性脑膜炎患者随机分为A组、B组和C组,分别静脉滴注左氧氟沙星400 mg、莫西沙星400 mg、莫西沙星600 mg,均1次·d-1,持续3个月,同时联合抗结核综合治疗,比较3组的治疗效果。采用汉密尔顿焦虑量表(HAMA量表)及健康测量量表(SF-36)评价患者的生活质量。结果与结论:采用莫西沙星400 mg或600 mg联合抗结核综合治疗对结核性脑膜炎效果优于左氧氟沙星结合综合治疗,是治疗结核性脑膜炎的有效方法,但不同剂量莫西沙星联合抗结核综合治疗效果无明显差异,选择400 mg莫西沙星即可达到良好的治疗效果。
Objective: To investigate the effect of different doses of moxifloxacin combined with anti-TB therapy on the prognosis of tuberculous meningitis and the quality of life of patients. Methods: Ninety patients with tuberculous meningitis were randomly divided into group A, group B and group C. The patients were divided into four groups: levofloxacin 400 mg, moxifloxacin 400 mg, moxifloxacin 600 mg, For 3 months, combined with anti-tuberculosis combined treatment, the treatment effect of the three groups were compared. Patients were assessed for quality of life using the Hamilton Anxiety Scale (HAMA Scale) and the Health Measurement Scale (SF-36). RESULTS AND CONCLUSION: The combination of moxifloxacin 400 mg or 600 mg combined with anti-tuberculosis treatment is superior to levofloxacin combined with comprehensive treatment for tuberculous meningitis, which is an effective method for the treatment of tuberculous meningitis. However, different doses of moxifloxacin combined with anti-TB No significant difference between the comprehensive treatment, the choice of 400 mg moxifloxacin to achieve good therapeutic effect.