论文部分内容阅读
正常骨代谢周期中,破骨细胞(OC)的骨吸收与成骨细胞(OB)的骨形成相互偶联,维持一种动态平衡,不断进行骨重建。当OC的骨吸收相对增强或OB的骨形成相对减弱,骨吸收大于骨形成导致骨质丢失时,将导致骨质疏松。近年来,随着细胞生物学和分子生物学研究的不断深入,细胞因子在骨代谢过程中的作用越来越受到人们的重视。细胞因子调控骨代谢过程中OB和OC的分化,增殖与功能活性,并通过自分泌、旁分泌和细胞黏附方式在骨重建中发挥重要作用。Osterix和脂联素便是新近发现的二种因子。
During normal bone metabolic cycles, bone resorption of osteoclasts (OC) is coupled with bone formation of osteoblasts (OB), maintaining a homeostasis and ongoing bone remodeling. When OC bone resorption relative increase or OB relatively weak bone formation, bone resorption than bone formation leads to bone loss, will lead to osteoporosis. In recent years, with the continuous research of cell biology and molecular biology, the role of cytokines in bone metabolism has drawn more and more attention. Cytokines regulate the differentiation, proliferation and functional activity of OB and OC during bone metabolism and play an important role in bone remodeling through autocrine, paracrine and cell adhesion methods. Osterix and adiponectin are two newly discovered factors.