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压制乳酸钙片最易产生花斑及揭盖现象,这对药片的外观和质量都有所影响。乳酸钙(C_6H_(10)O_6Ca·5H_2O)含有5分子结晶水,以重量计约佔总量的29.2%,由于干燥时干燥的程度不一致所含结晶水就不一样,这在制粒时就带来了困难。如由细粉以稀醇制粒时即产生发热现象,一般含结晶水少的,由于其要求恢复结晶水的趋势较大,遇水即迅速扩散,吸收,并在吸收的过程中产生较高的热量,一般温度可升高达60—70℃;含结晶水的由于恢复结晶水的趋势较小,故产生的热量较少,温度一般约升为30—50℃。但本身结晶水已经满足了5个分子的,制粒时则不再吸收水份或吸收得很少,这种情况就不产生热量,加入水份不易扩散,所制的颗粒呈软塊状,而在干燥过程中由于局部含水过多,温度升高就促使这
Suppressed calcium lactate most likely to produce piebald and uncover the phenomenon, which have an impact on the appearance and quality of the tablets. Calcium lactate (C_6H_ (10) O_6Ca_5H_2O) contains 5 molecules of crystal water, accounting for about 29.2% by weight. Because of inconsistencies in degree of drying during drying, the crystal water contained is different, It’s difficult. Such as the fine powder to dilute alcohol when the pellet that is generated when the phenomenon of heat, usually containing less water, due to its greater demand to restore the crystallization of water trends, that is, water quickly spread, absorption, and in the absorption process has a higher Of the heat, the general temperature can be increased up to 60-70 ℃; containing crystal water due to the smaller tendency to restore the crystallization of water, it produces less heat, the temperature is generally increased to about 30-50 ℃. But its own crystal water has satisfied five molecules, when the granulation is no longer absorbed or absorbed little water, in this case does not produce heat, water is not easy to spread, the particles are made of soft lumps, and In the drying process due to excessive partial water, the temperature is to promote this