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目的研究胰岛引流系统与胰腺外分泌的联系及胰腺门脉循环的意义。方法用微血管树脂／墨汁灌注扫描电镜／光镜观察、ＦＩＴＣ标记红细胞（ＦＩＴＣ－ＲＢＣ）荧光活体显微镜观察，对人、猴、狗、兔、鼠的胰岛血液引流通道进行了系统研究。结果胰岛的血液主要经胰岛的输出血管引流至外分泌腺泡区域，胰岛的引流系统存在对不同腺泡区域产生影响的三种类型。研究者根据胰岛引流系统的特征对其进行了分类及命名：①连续型：行程短、管径细，引流至胰岛周围的腺泡毛细血管区域；②聚合型：管径粗、行程长，引流至远离胰岛的腺泡毛细血管区域；③跨越型：越过小叶间隔引流至另一胰腺小叶的腺泡毛细血管区域，而这一小叶往往没有胰岛存在；胰岛的引流系统构成了胰岛－腺泡的门脉循环。结论胰岛有如此完善的联系外分泌腺泡的引流系统，提示；含有高浓度胰岛内分泌激素的胰岛血液，通过连续、聚合、跨越三种类型的引流系统，到达胰岛周围的腺泡区、远离胰岛的腺泡区以及无胰岛小叶，将对腺泡的机能产生影响，胰腺外分泌的机能有赖于胰岛内分泌激素的支持。结合亚热带地区糖尿病胰腺广泛纤维化病理损伤的特征，研究者推测：胰岛－外分泌微循环的损伤是糖尿病胰腺外分泌病理改变的基础。
Objective To study the relationship between islet drainage system and pancreatic exocrine and pancreatic portal circulation. Methods Microvessel resin / ink perfusion scanning electron microscopy / light microscopy and FITC-labeled red blood cells (FITC-RBC) fluorescence microscopy were used to study the islet blood flow channel of human, monkey, dog, rabbit and rat. Results The islet blood was mainly drained to the exocrine acinar region via the islet output vessel. There are three types of islet drainage system that affect different acinar regions. The researchers classified and nomenclature the pancreatic islet drainage system according to its characteristics: ① continuous type: short stroke, fine diameter and drainage to the area of acinar capillaries around pancreatic islets; ② polymeric type: coarse diameter, long stroke and drainage Far away from the pancreatic islets of the acinar capillary area; span type: across the interlobular septum drainage to the acinar capillary area of another pancreatic lobule, and this leaflets often do not have islets; islet drainage system constitutes islet - acinar Portal circulation. Conclusions The islet has such a perfect drainage system in connection with exocrine alveoli, suggesting that the islet blood containing high concentrations of islet endocrine hormones reaches the acinar zone around the pancreatic islets far and further from the islets by continuous, polymeric, and three-way drainage systems Acinar zone and no islet leaflets, will have an effect on the function of the acinar, pancreatic exocrine function depends on the islet endocrine hormone support. Combined with the characteristics of extensive fibrosis of pancreas in subtropical areas, we hypothesize that the damage of islet-exocrine microcirculation is the basis of the pathological changes of pancreatic exocrine in diabetic patients.