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在高原缺Ｏ2 时及低ＣＯ2 时 ,肺肥大细胞 (ＭＣ)脱颗粒影响肺动脉形态结构 ,在慢性阻塞性肺部疾病 (ＣＯＰＤ)时往往存在缺Ｏ2 高ＣＯ2 ,运动锻炼是康复疗法之一。为了探讨其机理 ,实验采用建立的慢性低Ｏ2 高ＣＯ2 大鼠模型及大鼠游泳锻炼 ,观察肺ＭＣ的形态改变和肺动脉结构
Pulmonary mast cells (MCs) degranulation affect the morphology of pulmonary arteries in the absence of O2 at high altitude and in low CO2. There is often a lack of O2 and hypercapnia in chronic obstructive pulmonary disease (COPD). Exercise training is one of the rehabilitation treatments. In order to explore its mechanism, we established the model of chronic hypoxia and hypercapnia in rats and rats swimming exercise to observe the morphological changes of pulmonary MC and pulmonary artery structure