论文部分内容阅读
为探讨α－２ａ－干扰素治疗血管瘤的作用机制，采用新鲜皮肤血管瘤组织进行血管内皮细胞组织块培养并传代，通过加入α－２ａ－干扰素，观察其对血管内皮细胞增殖的影响。结果：当α一２ａ一干扰素应用剂量为５ｘ１０ｔｕ／Ｌ和１×１０ｔｕ／Ｌ时，对血管内皮细胞的增殖有明显抑制作用。应用：５×１０ｕ／Ｌ，培养第１２ｄ后，血管内皮细胞数量和３Ｈ．ＴｄＲ掺入量明显低于对照组。结论：α－２ａ－干扰素可能是通过抑制血管瘤血管内皮细胞的增殖，促进血管瘤的退化而发挥治疗作用。
To explore the mechanism of α-2a-interferon in the treatment of hemangiomas, fresh cutaneous hemangiomas were used to culture vascular endothelial cells and passaged. The effects of α-2a-interferon on the proliferation of vascular endothelial cells were observed. Results: When α-2a interferon was applied at 5 × 10tu / L and 1 × 10tu / L, the proliferation of vascular endothelial cells was significantly inhibited. Application: 5 × 10u / L, after culturing for 12 days, the number of vascular endothelial cells and 3H. TdR incorporation was significantly lower than the control group. Conclusion: α-2a-interferon may play a therapeutic role by inhibiting the proliferation of vascular endothelial cells and promoting the degradation of hemangiomas.